Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.

@article{Macdonald1994MechanismsOA,
  title={Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.},
  author={Robert L Macdonald and Kevin M. Kelly},
  journal={Epilepsia},
  year={1994},
  volume={35 Suppl 4},
  pages={S41-50}
}
Clinically available antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed before 1980 appear to act on sodium (Na) channels, gamma-aminobutyric acid A (GABAA) receptors, or calcium (Ca) channels. Benzodiazepines and barbiturates enhance GABAA-receptor-mediated inhibition. Phenytoin, carbamazepine and, possibly, valproate (VPA) decrease high-frequency repetitive firing of action potentials by enhancing Na channel… CONTINUE READING
30 Citations
90 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 90 references

Current problems in epilepsy: new anticonvulsant drugs

  • GD Bartoszyk, N Meyerson, W Reimann, G Satzinger, RJ Porter, eds
  • 1986
Highly Influential
5 Excerpts

Effects of gabapentin on repetitive firing of action potentials and GABA responses of mouse central neurons in cell culture

  • AW Wamil, CP Taylor, MJ. McLean
  • Epilepsia
  • 1991
Highly Influential
14 Excerpts

Multiple cellular actions of gabapentin

  • AW Wamil, MJ McLean, CP. Taylor
  • Neurology
  • 1991
Highly Influential
14 Excerpts

Felbam - ate modulates glycine receptor function

  • WL Harmsworth, HH Wolf, EA Swinyard, HS White
  • Epilepsia
  • 1993
1 Excerpt

Similar Papers

Loading similar papers…