Mechanisms of action of antimicrobials: focus on fluoroquinolones.

  title={Mechanisms of action of antimicrobials: focus on fluoroquinolones.},
  author={David C. Hooper},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={32 Suppl 1},
  • David C. Hooper
  • Published 2001 in
    Clinical infectious diseases : an official…
Five bacterial targets have been exploited in the development of antimicrobial drugs: cell wall synthesis, protein synthesis, ribonucleic acid synthesis, deoxyribonucleic acid (DNA) synthesis, and intermediary metabolism. Because resistance to drugs that interact with these targets is widespread, new antimicrobials and an understanding of their mechanisms of action are vital. The fluoroquinolones are the only direct inhibitors of DNA synthesis; by binding to the enzyme-DNA complex, they… CONTINUE READING

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