Mechanisms of action of aminoglycoside antibiotics in eucaryotic protein synthesis.

@article{Eustice1984MechanismsOA,
  title={Mechanisms of action of aminoglycoside antibiotics in eucaryotic protein synthesis.},
  author={David Eustice and James M Wilhelm},
  journal={Antimicrobial agents and chemotherapy},
  year={1984},
  volume={26 1},
  pages={53-60}
}
Tetrahymena thermophila is a eucaryotic organism that is highly susceptible to growth inhibition by aminoglycoside antibiotics. Concentrations of paromomycin, gentamicin G418, and hygromycin B at 22, 10, and 17 microM, respectively, inhibited growth by 50%. A combination of in vitro and in vivo methods was used to determine the mechanisms of action of these aminoglycoside antibiotics on protein synthesis in T. thermophila. Analysis of polysome profiles from paromomycin- and gentamicin G418… CONTINUE READING

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