Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.

  • David E. Leaf, David S Goldfarb
  • Published 2007 in Journal of applied physiology
Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is the most commonly used and best-studied agent for the amelioration of acute mountain sickness (AMS). The actual mechanisms by which acetazolamide reduces symptoms of AMS, however, remain unclear. Traditionally, acetazolamide's efficacy has been attributed to inhibition of CA in the kidneys… (More)