Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.

@article{ReyesGordillo2014MechanismsOA,
  title={Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.},
  author={Karina Reyes-Gordillo and Ruchi Shah and Jaime Arellanes-Robledo and Zamira Helena Hern{\'a}ndez-Nazara and Ana Rosa Rinc{\'o}n-S{\'a}nchez and Yutaka Inagaki and Marcos Rojkind and M Raj Lakshman},
  journal={The American journal of pathology},
  year={2014},
  volume={184 5},
  pages={1458-67}
}
Alcohol-induced liver fibrosis and eventually cirrhosis is a leading cause of death. Acetaldehyde, the first metabolite of ethanol, up-regulates expression of the human α2(I) collagen gene (COL1A2). Early acetaldehyde-mediated effects involve phosphorylation and nuclear translocation of SMAD3/4-containing complexes that bind to COL1A2 promoter to induce fibrogenesis. We used human and mouse hepatic stellate cells to elucidate the mechanisms whereby acetaldehyde up-regulates COL1A2 by modulating… CONTINUE READING
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