Mechanisms of actio of poly-plat, a novel platinum antineoplastic agent.

@article{Telgenhoff2002MechanismsOA,
  title={Mechanisms of actio of poly-plat, a novel platinum antineoplastic agent.},
  author={Dale J Telgenhoff and Surinder K. Aggarwal},
  journal={Anticancer research},
  year={2002},
  volume={22 4},
  pages={2167-72}
}
Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture. These cells were treated with Poly-Plat (10 microg/ml) or Cisplatin (10 mg/ml) for 2-5 days. Peritoneal macrophages were treated with Cisplatin (10 microg/ml) or Poly-Plat (10 microg/ml) for 2 hours and allowed to grow in normal medium for 48 hours… CONTINUE READING

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