Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure.

@article{Luo2007MechanismsOA,
  title={Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure.},
  author={Jianzhu Luo and Bradford G. Hill and Yan Gu and Jian Cai and Sanjay Kumar Srivastava and Aruni Bhatnagar and Sumanth D. Prabhu},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 6},
  pages={H3673-84}
}
Aldehydes are ubiquitous pollutants generated during the combustion of organic materials and are present in air, water, and food. Several aldehydes are also endogenous products of lipid peroxidation and by-products of drug metabolism. Despite well-documented high reactivity of unsaturated aldehydes, little is known regarding their cardiovascular effects and their role in cardiac pathology. Accordingly, we examined the myocardial effects of the model unsaturated aldehyde acrolein. In closed… CONTINUE READING