Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

  title={Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.},
  author={Yuchao Xie and Mitchell R Mcgill and Kenneth Dorko and Sean C. Kumer and Timothy M. Schmitt and Jameson Forster and Hartmut Jaeschke},
  journal={Toxicology and applied pharmacology},
  volume={279 3},
UNLABELLED Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. Numerous studies have been conducted to investigate the mechanisms of injury after APAP overdose in various animal models; however, the importance of these mechanisms for humans remains unclear. Here we investigated APAP hepatotoxicity using freshly isolated primary human hepatocytes (PHH) from either donor livers or liver resections. PHH were exposed to 5mM, 10mM or 20mM APAP… CONTINUE READING
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