Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.

@article{Ramachandran2017MechanismsOA,
  title={Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.},
  author={Anup Ramachandran and Hartmut Jaeschke},
  journal={Journal of clinical and translational research},
  year={2017},
  volume={3 Suppl 1},
  pages={157-169}
}
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation. Studies in the mouse model, which closely reproduces the human condition, have shown that hepatotoxicity is initiated by formation of a reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which depletes cellular glutathione and forms protein adducts on mitochondrial proteins. This leads… CONTINUE READING
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