Mechanisms of T cell development and transformation.

@article{Koch2011MechanismsOT,
  title={Mechanisms of T cell development and transformation.},
  author={Ute Koch and Freddy Radtke},
  journal={Annual review of cell and developmental biology},
  year={2011},
  volume={27},
  pages={
          539-62
        }
}
T cells are the key mediators in cell-mediated immunity. Their development and maturation involve a complex variety of interactions with nonlymphoid cell products and receptors. Highly specialized to defend against bacterial and viral infections, T cells also mediate immune surveillance against tumor cells and react to foreign tissues. T cell progenitors originate in the bone marrow and, through a series of defined and coordinated developmental stages, enter the thymus, differentiate, undergo… CONTINUE READING
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