Mechanisms of Resistance to Quinolones

  title={Mechanisms of Resistance to Quinolones},
  author={Emmanuelle Cambau and Ludwig Gutmann},
Mechanisms of resistance to the quinolones have been described for several bacterial species, but mainly for Escherichia coli and Staphylococcus aureus. Two principal mechanisms have been described: 1) alteration of the DNA gyrase, which is the target site of the quinolones; and 2) diminished accumulation in the cell as a result of either decreased uptake or increased efflux. Alteration of DNA gyrase is usually the result of a mutation in the gyrA, or more rarely, the gyrB gene. All… CONTINUE READING

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A novel gyrA point mutation confers resistance to fluoroquinolones but not to nal - idixic acid in Escherichia coli . Abstract no . 96

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