Mechanisms of Resistance to Quinolones

@article{Cambau1993MechanismsOR,
  title={Mechanisms of Resistance to Quinolones},
  author={Emmanuelle Cambau and Ludwig Gutmann},
  journal={Drugs},
  year={1993},
  volume={45},
  pages={15-23}
}
Mechanisms of resistance to the quinolones have been described for several bacterial species, but mainly for Escherichia coli and Staphylococcus aureus. Two principal mechanisms have been described: 1) alteration of the DNA gyrase, which is the target site of the quinolones; and 2) diminished accumulation in the cell as a result of either decreased uptake or increased efflux. Alteration of DNA gyrase is usually the result of a mutation in the gyrA, or more rarely, the gyrB gene. All… CONTINUE READING

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A novel gyrA point mutation confers resistance to fluoroquinolones but not to nal - idixic acid in Escherichia coli . Abstract no . 96

  • E Cambau, F Bordon, E Collatz, L Gutmann
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Mechanisms of qui no lone - resistance in clinical and veterinary isolates of Salmonella

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Up - regulation of norA 1199 results in fluoroquinolones ( FQ ) resistance in Staphylococcus aureus ( SA )

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