Mechanisms of Resistance to Kinase Inhibitors and Strategies to Prevent the Development of Drug Resistance

@inproceedings{Kobayashi2018MechanismsOR,
  title={Mechanisms of Resistance to Kinase Inhibitors and Strategies to Prevent the Development of Drug Resistance},
  author={Hisakazu Kobayashi and Kenichi Iwai and Emiko Niiro and Shin Morioka and Yosuke Yamada and Kimikazu Ogawa and Natsumi Kawahara},
  year={2018}
}
Targeting mutant proteins and associated signaling pathways of driver oncogenes by small molecule kinase inhibitors (KIs) are a promising strategy of cancer therapy. However, despite the initial success of treatment, KIs often become ineffective as intrinsic and acquired resistance. This article reviews the English-language literature to explore the underlying mechanisms of drug resistance and to present a challenge for developing drugs to overcome resistance. Mechanisms of acquired resistance… CONTINUE READING

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