Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

@article{Ayata1997MechanismsOR,
  title={Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice},
  author={Cenk Ayata and Gamze Ayata and Hideaki Hara and Russell T Matthews and Michael Beal and Robert Ferrante and Matthias Endres and Ahyoung Kim and Richard H. Christie and Christian Waeber and Paul Lee Huang and Bradley T. Hyman and Michael Ann Moskowitz},
  journal={The Journal of Neuroscience},
  year={1997},
  volume={17},
  pages={6908 - 6917}
}
  • Cenk Ayata, Gamze Ayata, +10 authors Michael Ann Moskowitz
  • Published 1997
  • Medicine, Biology
  • The Journal of Neuroscience
  • We investigated the role of neuronal (type I) nitric oxide synthase (nNOS) in NMDA-mediated excitotoxicity in wild-type (SV129 and C57BL/6J) and type I NOS knock-out (nNOS−/−) mice and examined its relationship to apoptosis. Excitotoxic lesions were produced by intrastriatal stereotactic NMDA microinjections (10–20 nmol). Lesion size was dose- and time-dependent, completely blocked by MK-801 pretreatment, and smaller in nNOS knock-out mice compared with wild-type littermates (nNOS+/+, 11.7 ± 1… CONTINUE READING

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