Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export

@article{Pemberton2005MechanismsOR,
  title={Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export},
  author={L. Pemberton and B. Paschal},
  journal={Traffic},
  year={2005},
  volume={6}
}
Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is mediated by a superfamily of transport receptors known collectively as karyopherins. Karyopherins bind to their cargoes by recognition of specific nuclear localization signals or nuclear export signals. Transport through the nuclear pore complex is facilitated by transient interactions between the karyopherins and the nuclear pore complex. The interactions of karyopherins with their cargoes are regulated by the… Expand
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