Mechanisms of Ras membrane organization and signalling: Ras on a rocker.

  title={Mechanisms of Ras membrane organization and signalling: Ras on a rocker.},
  author={Daniel Abankwa and Alemayehu A. Gorfe and John F Hancock},
  journal={Cell cycle},
  volume={7 17},
Understanding the signalling function of Ras GTPases has been the focus of much research for over 20 years. Both the catalytic domain and the membrane anchoring C terminal hypervariable region (HVR) of Ras are necessary for its cellular function. However, while the highly conserved catalytic domain has been characterized in atomic detail, the structure of the full-length membrane-bound Ras has remained elusive. Lack of structural knowledge on the full-length protein limited our understanding of… CONTINUE READING
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