Mechanisms of Proteinuria: Vascular Permeability Factor in Congenital Nephrotic Syndrome of the Finnish Type

@article{Haltia1996MechanismsOP,
  title={Mechanisms of Proteinuria: Vascular Permeability Factor in Congenital Nephrotic Syndrome of the Finnish Type},
  author={Anni Haltia and M S Solin and Hannu J Jalanko and Christer Holmberg and Aaro Miettinen and Harry Holth{\"o}fer},
  journal={Pediatric Research},
  year={1996},
  volume={40},
  pages={652-657}
}
Vascular permeability factor (VPF) is the most potent known mediator of vessel wall permeability. In the kidney, it is expressed preferentially in the glomerular visceral epithelial cells. The present study was designed to clarify the proposed role of VPF in diseases with increased glomerular permeability as here exemplified by the congenital nephrotic syndrome of the Finnish type (CNF). For this, we studied the expression levels and the sites of synthesis of VPF and its kinase-insert domain… CONTINUE READING
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