Mechanisms of Prostate Tumorigenesis: Roles for Transcription Factors Nkx3.1 and Egr1

@article{Abdulkadir2005MechanismsOP,
  title={Mechanisms of Prostate Tumorigenesis: Roles for Transcription Factors Nkx3.1 and Egr1},
  author={S. Abdulkadir},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1059}
}
  • S. Abdulkadir
  • Published 2005
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: Recent developments in the generation and analysis of transgenic mouse models have improved our understanding of the early stages of prostate tumorigenesis. Analysis of models based on the homeodomain protein Nkx3.1 and the zinc finger protein Egr1 suggests that these transcription factors play distinct roles in the initiation and progression of precursor prostatic intraepithelial neoplasia (PIN) lesions, respectively. Nkx3.1 is a candidate prostate tumor suppressor gene (TSG) that… Expand
45 Citations
Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis.
Haploinsufficient Prostate Tumor Suppression by Nkx3.1
Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice
Advances in mouse models of prostate cancer
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Roles for Nkx3.1 in prostate development and cancer.
Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia
Interaction of Nkx3.1 and p27kip1 in prostate tumor initiation.
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
Impaired prostate tumorigenesis in Egr1-deficient mice
...
1
2
3
4
...