Mechanisms of Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Ritonavir‐Enhanced Tipranavir

@article{Vourvahis2007MechanismsOP,
  title={Mechanisms of Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Ritonavir‐Enhanced Tipranavir},
  author={M. Vourvahis and A. Kashuba},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2007},
  volume={27}
}
  • M. Vourvahis, A. Kashuba
  • Published 2007
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
  • Tipranavir is a nonpeptidic protease inhibitor that has activity against human immunodeficiency virus strains resistant to multiple protease inhibitors. Tipranavir 500 mg is coadministered with ritonavir 200 mg. Tipranavir is metabolized by cytochrome P450 (CYP) 3A and, when combined with ritonavir in vitro, causes inhibition of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A in addition to induction of glucuronidase and the drug transporter P‐glycoprotein. As a result, drug‐drug interactions… CONTINUE READING
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