Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

@article{Andersson2011MechanismsOP,
  title={Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction},
  author={Karl Erik Andersson},
  journal={Pharmacological Reviews},
  year={2011},
  volume={63},
  pages={811 - 859}
}
Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents, both autonomic and somatic, and supraspinal influences from visual, olfactory, and imaginary stimuli. Several central transmitters are involved in the erectile control. Dopamine, acetylcholine, nitric oxide (NO), and peptides, such as oxytocin and adrenocorticotropin/α-melanocyte-stimulating hormone, have a facilitatory role, whereas serotonin may be either facilitatory or inhibitory, and enkephalins… Expand
Erectile Dysfunction in Diabetes : An Overview
Erectile dysfunction is the persistent inability to achieve erection hard enough for sexual intercourse. Penile erection is initiated by various stimuli which leads to the release of NO from theExpand
Modulation of Dopaminergic Pathways to Treat Erectile Dysfunction.
TLDR
Modulation of the dopaminergic pathways provides a possibility to improve the treatment of ED and can be used to alleviate sexual symptoms caused by other antidepressant medication. Expand
Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?
TLDR
A detailed description of the underlying biology of erectile function is provided with a focus on the role of endocrine signalling, exploring the potential link between EDCs and ED based on animal and human studies. Expand
Erectile dysfunction and the biochemical/molecular/ regulation of human penile arteries
TLDR
Examination proves CNP is an EDHF in human penile resistance vessels which plays an essential role in the reduction of vessel tone supporting erection and development of the surgical technique in the Department of Urology has lead to better functional and esthetical results. Expand
Penile veins are the principal component in erectile rigidity: a study of penile venous stripping on defrosted human cadavers.
TLDR
This study demonstrates that the human erection is fundamentally a mechanical event contingent on venous competence, and eliminates the influence of hormonal, arterial, neurological, sinusoidal, pharmacological, and psychological factors. Expand
Controversies in low intensity extracorporeal shockwave therapy for erectile dysfunction
TLDR
Low intensity extracorporeal shockwave therapy (LiESWT) is a novel treatment for ED that aims to reverse the pathophysiology of ED at the cellular level to provide longterm improvement and return of spontaneous erectile function. Expand
Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review
TLDR
Evidence is gathered that the use of modulating agents of these channels are involved in relaxation of the cavernous smooth muscle cell and, consequent penile erection, suggesting thatThese channels are promising therapeutic targets for the treatment of erectile dysfunction. Expand
Screening of new compounds for the management of erectile dysfunction
TLDR
Compounds those relax isolated rat corpus cavernosum smooth muscles in rat in vitro may increase penile erection in humans and compounds those increase intracavernosal pressure by relaxing erectile smooth muscle and penile arteries in rat may increase erectile function in humans. Expand
Mechanisms in Erectile Function and Dysfunction: An Overview
TLDR
The basic penile physiology and the emergent mechanisms associated to pathophisiology of vasculogenic ED are described and penile anatomy and physiology will be summarized in order to review the new insights regarding pathways and critical modifications observed in ED condition. Expand
Normal male sexual function: emphasis on orgasm and ejaculation.
TLDR
The physiology of orgasm and ejaculation is described, detailing the neuronal, neurochemical, and hormonal control of the ejaculation process. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 724 REFERENCES
Pharmacology of penile erection.
TLDR
Dopamine receptors in central nervous centers participating in the initiation of erection have been targeted for the treatment of ED, and Apomorphine, administered sublingually, is the first of such drugs. Expand
Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides
TLDR
Despite some recent progress, more has still to be done to clarify the role played by neurotransmitters and neuropeptides at peripheral and central levels in the control of this primary sexual function. Expand
Erectile physiological and pathophysiological pathways involved in erectile dysfunction.
TLDR
An important role for RhoA/Rho kinase in the regulation of cavernosal smooth muscle tone is suggested and changes in this pathway may contribute to ED in various patient subgroups, eg diabetes and vascular disease. Expand
Neural control of penile erection.
TLDR
Neuroendocrine regulation may vary depending on the context in which erection occurs, for example, coitus, in response to extrinsic or psychogenic stimuli, and rapid eye movement sleep. Expand
Penile Arteries and Erection
TLDR
Erectile dysfunction shares arterial risk factors with ischaemic heart disease, and diabetes, age, and hypercholesterolaemia are associated with impairment of both neurogenic and endothelium-dependent vasodilator mechanisms in corpus cavernosum. Expand
Central noradrenergic control of penile erection.
TLDR
The most robust evidence is that central inhibition of alpha-2 adrenoceptors facilitates sexual function and pharmacological experiments suggest a modulatory role for noradrenaline in the control of penile erection either in the brain or in the spinal cord. Expand
Central neural regulation of penile erection
TLDR
The shift from flaccidity to erection suggests relations among these neuronal populations in response to a variety of informations, and a spinal network consisting of primary afferents from the genitals, spinal interneurons and sympathetic, parasympathetic and somatic nuclei is hypothesize. Expand
Role of adenosine signaling in penile erection and erectile disorders.
TLDR
A general role of exogenous and endogenous adenosine signaling in normal penile erection is suggested and represents a potentially important diagnostic and therapeutic target for the treatment of ED and priapism. Expand
Neural control of erection
TLDR
The convergence of information from peripheral and supra-spinal origins onto spinal neurones is very likely activating more specifically the spinal pro-erectile network, which is prone to regulate penile erection in more integrated and coordinated responses of the body, as those occurring during sexual behaviour. Expand
Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus
TLDR
The findings show that the paraventricular nucleus of the hypothalamus plays an important role in the control of erectile function and sexual activity, and may have great significance in terms of a human perspective for the treatment of erectiles dysfunction. Expand
...
1
2
3
4
5
...