Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

  title={Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction},
  author={Karl Erik Andersson},
  journal={Pharmacological Reviews},
  pages={811 - 859}
  • K. Andersson
  • Published 1 December 2011
  • Biology, Medicine
  • Pharmacological Reviews
Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents, both autonomic and somatic, and supraspinal influences from visual, olfactory, and imaginary stimuli. Several central transmitters are involved in the erectile control. Dopamine, acetylcholine, nitric oxide (NO), and peptides, such as oxytocin and adrenocorticotropin/α-melanocyte-stimulating hormone, have a facilitatory role, whereas serotonin may be either facilitatory or inhibitory, and enkephalins… 

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