Antimicrobial Agents of Fluoroquinolone Family in Clinical Practice [in Russian
- E. R. Padeiskaya, V. P. Yakovlev
- 1998
3 Excerpts
Mechanisms of Pefloxacin-Induced Pain
- Published 2004 in Bulletin of Experimental Biology and Medicine
Abstract
In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late… (More)