Mechanisms of Pefloxacin-Induced Pain

@article{Kukushkin2004MechanismsOP,
  title={Mechanisms of Pefloxacin-Induced Pain},
  author={M.L. Kukushkin and S. I. Igonkina and T. A. Guskova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={137},
  pages={336-338}
}
In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late component of nociceptive flexor reflex. Intrathecal application of pefloxacin in a dose of 20 μg provoked allodynia, while the higher dose of… 

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