Mechanisms of Pefloxacin-Induced Pain
@article{Kukushkin2004MechanismsOP, title={Mechanisms of Pefloxacin-Induced Pain}, author={M. L. Kukushkin and S. I. Igonkina and T. A. Guskova}, journal={Bulletin of Experimental Biology and Medicine}, year={2004}, volume={137}, pages={336-338} }
In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late component of nociceptive flexor reflex. Intrathecal application of pefloxacin in a dose of 20 μg provoked allodynia, while the higher dose of…
References
SHOWING 1-9 OF 9 REFERENCES
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists
- Biology, PsychologyPain
- 1989
Peripheral Neuropathy Associated with Fluoroquinolones
- MedicineThe Annals of pharmacotherapy
- 2001
These cases suggest a possible association between fluoroquinolone antibiotics and severe, long-term adverse effects involving the PNS as well as other organ systems, and should prompt immediate discontinuation of the agent used.
Structure-activity and structure-side-effect relationships for the quinolone antibacterials.
- ChemistryThe Journal of antimicrobial chemotherapy
- 1994
The various structural features of the quinolones which govern antibacterial efficacy and influence the side-effect profile are delineated and summarized at the molecular level and those groups which mutually improve efficacy while reducing side-effects are identified.
Overview of Clinical Experience of Pefloxacin in Gastrointestinal Infections
- Medicine, Biology
- 1996
In limited trials, pefloxacin has been successfully used for the treatment of bacterial enteric infection and febrile dysenteric diarrhoea (caused by strains of Shigella and Salmonella), and typhoid fever.
Animal models of nociception.
- Psychology, BiologyPharmacological reviews
- 2001
It is concluded that although the neural basis of the most used tests is poorly understood, their use will be more profitable if pain is considered within, rather than apart from, the body's homeostatic mechanisms.
GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
- Bulletin of Experimental Biology and Medicine, No
- 1989
Antimicrobial Agents of Fluoroquinolone Family in Clinical Practice [in Russian
- 1998