Mechanisms of NSAID-Induced Hepatotoxicity

@article{Boelsterli2002MechanismsON,
  title={Mechanisms of NSAID-Induced Hepatotoxicity},
  author={Urs Alex Boelsterli},
  journal={Drug Safety},
  year={2002},
  volume={25},
  pages={633-648}
}
  • Urs Alex Boelsterli
  • Published in Drug safety 2002
  • Medicine
  • Drug Safety
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with idiosyncratic hepatotoxicity in susceptible patients. The molecular mechanisms underlying this toxicity have not yet been fully elucidated. However, experimental evidence suggests that they include increased concentration of the drugs in the hepatobiliary compartment, formation of reactive metabolites that covalently modify proteins and produce oxidative stress, and mitochondrial injury. Genetic and/or acquired patient… CONTINUE READING

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