Mechanisms of Mineralocorticoid Action

@article{Fuller2005MechanismsOM,
  title={Mechanisms of Mineralocorticoid Action},
  author={P. Fuller and M. Young},
  journal={Hypertension},
  year={2005},
  volume={46},
  pages={1227-1235}
}
Sodium transport in epithelial tissues is regulated by the physiological mineralocorticoid aldosterone. The response to aldosterone is mediated by the mineralocorticoid receptor (MR), for which the crystal structure of the ligand-binding domain has recently been established. The classical mode of action for this receptor involves the regulation of gene transcription. Several genes have now been shown to be regulated by aldosterone in epithelial tissues. Of these, the best characterized is serum… Expand
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TLDR
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TLDR
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TLDR
Evidence for possible mechanisms conferring ligand specificity in the context of mineralocorticoid‐induced hypertension and the brain are discussed and factors (or mechanisms) intrinsic to the receptor are discussed. Expand
Novel interactions of the mineralocorticoid receptor
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  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • 2015
TLDR
The successful identification of the structural basis of antagonism and of ligand-specific interactions of the MR may provide the basis for the development of novel MR ligands with tissue specificity. Expand
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The mineralocorticoid receptor (MR) and aldosterone play a critical role in the regulation of plasma volume homeostasis and are critical for the control of normal physiological regulation bloodExpand
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TLDR
Investigation of the ET-1 gene in vivo as a potential direct aldosterone-regulated target gene in the kidney and colon suggests that it may play an important role in ald testosterone-regulated ion homeostasis. Expand
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TLDR
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