Mechanisms of MYC stabilization in human malignancies.

  title={Mechanisms of MYC stabilization in human malignancies.},
  author={Melissa R Junttila and Jukka Westermarck},
  journal={Cell cycle},
  volume={7 5},
MYC is a pleiotropic transcription factor that has been linked to a diverse range of cellular functions, such as cell cycle regulation, proliferation, growth, differentiation and metabolism. Not surprisingly, aberrant MYC signaling has been observed in human cancers and MYC has been demonstrated to promote cell transformation and tumor progression. Here we discuss recent discoveries that have expanded our knowledge of MYC protein stability. In particular we focus on mechanisms that might… CONTINUE READING