Mechanisms of MPP(+) incorporation into cerebellar granule cells.

@article{GonzlezPolo2001MechanismsOM,
  title={Mechanisms of MPP(+) incorporation into cerebellar granule cells.},
  author={Rosa Ana Gonz{\'a}lez-Polo and Alfonso Mora and Nicola Clemente and Guadalupe Sabio and Francisco Centeno and Germ{\'a}n Soler and Jos{\'e} M Fuentes},
  journal={Brain research bulletin},
  year={2001},
  volume={56 2},
  pages={119-23}
}
Exposure of cerebellar granule cells to 1-methyl-4-phenylpiridinium (MPP(+)) results in cell death. We have studied the implication of various membrane transporter systems on MPP(+) neurotoxicity, including the dopamine transporter system (DAT) and cationic amino acid transporters (CAT). We have showed a partial protection against MPP(+) toxicity when the dopamine transporter is inhibited by 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]4-(3-phenylpropyl)piperazinedihydrochloride (GBR-12909). However… CONTINUE READING
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