Mechanisms of Lysosomal Enzyme Release from Human Leukocytes

@article{Zurier1973MechanismsOL,
  title={Mechanisms of Lysosomal Enzyme Release from Human Leukocytes},
  author={Robert B. Zurier and Sylvia T. Hoffstein and Gerald Weissmann},
  journal={The Journal of Cell Biology},
  year={1973},
  volume={58},
  pages={27 - 41}
}
In order to study mechanisms underlying selective enzyme release from human leukocytes during phagocytosis, the effects were studied of compounds which affect microtubule integrity or the accumulation of cyclic nucleotides. Human leukocytes selectively extrude lysosomal enzymes (beta-glucuronidase) from viable cells during phagocytosis of zymosan or immune complexes, or upon encounter with immune complexes dispersed along a non-phagocytosable surface such as a millipore filter. In each… CONTINUE READING
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