Mechanisms of Jak/STAT signaling in immunity and disease.

  title={Mechanisms of Jak/STAT signaling in immunity and disease.},
  author={Alejandro V Villarino and Yuka Kanno and John R Ferdinand and John J O'Shea},
  journal={Journal of immunology},
  volume={194 1},
More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for membrane-to-nucleus signaling and explains how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
67 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 67 extracted citations

Similar Papers

Loading similar papers…