Mechanisms of Jak/STAT signaling in immunity and disease.

@article{Villarino2015MechanismsOJ,
  title={Mechanisms of Jak/STAT signaling in immunity and disease.},
  author={Alejandro V Villarino and Yuka Kanno and John R Ferdinand and John J O'Shea},
  journal={Journal of immunology},
  year={2015},
  volume={194 1},
  pages={21-7}
}
More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for membrane-to-nucleus signaling and explains how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene… CONTINUE READING
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