Mechanisms of Insulin Action and Insulin Resistance.

@article{Petersen2018MechanismsOI,
  title={Mechanisms of Insulin Action and Insulin Resistance.},
  author={Max C. Petersen and Gerald I. Shulman},
  journal={Physiological reviews},
  year={2018},
  volume={98 4},
  pages={
          2133-2223
        }
}
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have matured, coalescing into solid and fertile ground for clinical application; others remain incompletely investigated and scientifically controversial. Here, we attempt to synthesize this work to guide further mechanistic investigation and to inform the development of novel therapies for type 2 diabetes… 
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