Mechanisms of Induction and Expression of Long-Term Depression at GABAergic Synapses in the Neonatal Rat Hippocampus

@article{Caillard1999MechanismsOI,
  title={Mechanisms of Induction and Expression of Long-Term Depression at GABAergic Synapses in the Neonatal Rat Hippocampus},
  author={Olivier Caillard and Yezekiel Ben‐Ari and J. L. Ga{\"i}arsa},
  journal={The Journal of Neuroscience},
  year={1999},
  volume={19},
  pages={7568 - 7577}
}
Synaptic plasticity at excitatory glutamatergic synapses is believed to be instrumental in the maturation of neuronal networks. Using whole-cell patch-clamp recordings, we have studied the mechanisms of induction and expression of long-term depression at excitatory GABAergic synapses in the neonatal rat hippocampus (LTDGABA-A). We report that the induction of LTDGABA-A requires a GABAA receptor-mediated membrane depolarization, which is necessary to remove the Mg2+ block from postsynaptic NMDA… Expand
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