Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.

@article{Kmita2000MechanismsOH,
  title={Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.},
  author={Marie Kmita and Frank van der Hoeven and J{\'o}zsef Z{\'a}k{\'a}ny and Robb K Krumlauf and Denis Duboule},
  journal={Genes & development},
  year={2000},
  volume={14 2},
  pages={198-211}
}
Transposition of Hoxd genes to a more posterior (5') location within the HoxD complex suggested that colinearity in the expression of these genes was due, in part, to the existence of a silencing mechanism originating at the 5' end of the cluster and extending towards the 3' direction. To assess the strength and specificity of this repression, as well as to challenge available models on colinearity, we inserted a Hoxb1/lacZ transgene within the posterior HoxD complex, thereby reconstructing a… CONTINUE READING

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