Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection

@article{Dyer2008MechanismsOH,
  title={Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection},
  author={Wayne B. Dyer and John James Zaunders and Fang Fang Yuan and Bin Wang and Jennifer C. Learmont and Andrew F. Geczy and Nitin K Saksena and Dale A. McPhee and Paul R. Gorry and John Stephen Sullivan},
  journal={Retrovirology},
  year={2008},
  volume={5},
  pages={112 - 112}
}
Elite non-progressors (plasma viral load <50 copies/ml while antiretroviral naive) constitute a tiny fraction of HIV-infected individuals. After 12 years follow-up of a cohort of 13 long-term non-progressors (LTNP) identified from 135 individuals with transfusion-acquired HIV infection, 5 remained LTNP after 23 to 26 years infection, but only 3 retained elite LTNP status. We examined the mechanisms that differentiated delayed progressors from LTNP in this cohort. A survival advantage was… CONTINUE READING

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