Mechanisms of HIV-1 Nef Function and Intracellular Signaling

  title={Mechanisms of HIV-1 Nef Function and Intracellular Signaling},
  author={John L. Foster and Sarah J. Denial and Brenda R. S. Temple and J. Victor Garcia},
  journal={Journal of Neuroimmune Pharmacology},
Advances in the last several years have enhanced mechanistic understanding of Nef-induced CD4 and MHCI downregulation and have suggested a new paradigm for analyzing Nef function. In both of these cases, Nef acts by forming ternary complexes with significant contributions to stability imparted by non-canonical interactions. The mutational analyses and binding assays that have led to these conclusions are discussed. The recent progress has been dependent on conservative mutations and multi… CONTINUE READING

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  • YT Kwak, A Raney, +4 authors JL Foster
  • 2010
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