Mechanisms of HCV survival in the host

  title={Mechanisms of HCV survival in the host},
  author={Ella H. Sklan and Prista Charuworn and Philip S. Pang and Jeffrey S. Glenn},
  journal={Nature Reviews Gastroenterology &Hepatology},
HCV infection is an important cause of liver disease worldwide—nearly 80% of infected patients develop chronic liver disease, which leads to the development of liver cirrhosis and hepatocellular carcinoma. The ability of HCV to persist within a host is believed to be related to the numerous mechanisms by which it evades the immune response of the host. These mechanisms can be divided into defensive and offensive strategies. Examples of defensive mechanisms include replication within enclosed… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 119 references

The global burden of hepatitis C.

Liver international : official journal of the International Association for the Study of the Liver • 2009

Interferon signaling and treatment outcome in chronic hepatitis C.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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