Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila.

@article{Peri2002MechanismsOG,
  title={Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila.},
  author={Francesca Peri and Martin Technau and Siegfried Roth},
  journal={Development},
  year={2002},
  volume={129 12},
  pages={2965-75}
}
The restriction of Pipe, a potential glycosaminoglycan-modifying enzyme, to ventral follicle cells of the egg chamber is essential for dorsoventral axis formation in the Drosophila embryo. pipe repression depends on the TGFalpha-like ligand Gurken, which activates the Drosophila EGF receptor in dorsal follicle cells. An analysis of Raf mutant clones shows that EGF signalling is required cell-autonomously in all dorsal follicle cells along the anteroposterior axis of the egg chamber to repress… CONTINUE READING