Mechanisms of Extracellular Oncogenic Dysregulation and Antibody Targeting of the Epidermal Growth Factor Receptor

@inproceedings{Bagchi2016MechanismsOE,
  title={Mechanisms of Extracellular Oncogenic Dysregulation and Antibody Targeting of the Epidermal Growth Factor Receptor},
  author={Atrish Bagchi},
  year={2016}
}
Regulation of the Epidermal Growth Factor Receptor (EGFR) by its growth factor ligands is critical in many biological processes, including development and tissue maintenance and growth. Aberrant overexpression or activation by mutation of EGFR is associated with many human tumors. In these contexts, constitutive signaling can lead to cellular transformation and oncogenesis, thereby driving the cancer. The EGFR is the target of several existing or developing cancer therapies or immunotherapies… CONTINUE READING

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