Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches

Abstract

UNLABELLED This review summarizes the results found in studies investigating the enzymatic activation of two genotoxic nitro-aromatics, an environmental pollutant and carcinogen 3-nitrobenzanthrone (3-NBA) and a natural plant nephrotoxin and carcinogen aristolochic acid I (AAI), to reactive species forming covalent DNA adducts. Experimental and theoretical… (More)
DOI: 10.3390/ijms150610271

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@inproceedings{Stiborov2014MechanismsOE, title={Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches}, author={Marie Stiborov{\'a} and Eva Frei and Heinz Hans Schmeiser and Volker M Arlt and V{\'a}clav Mart{\'i}nek}, booktitle={International journal of molecular sciences}, year={2014} }