Mechanisms of ER stress-induced apoptosis in atherosclerosis.

  title={Mechanisms of ER stress-induced apoptosis in atherosclerosis.},
  author={Christopher M Scull and Ira Tabas},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={31 12},
Endoplasmic reticulum (ER) stress is triggered by perturbations in ER function such as those caused by protein misfolding or by increases in protein secretion. Eukaryotic cells respond to ER stress by activating 3 ER-resident proteins, activating transcription factor-6, inositol requiring protein-1, and protein kinase RNA-like ER kinase (PERK). These proteins direct signaling pathways that relieve ER stress in a process known as the unfolded protein response (UPR). In pathological settings… CONTINUE READING


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