Mechanisms of EF-Tu, a pioneer GTPase.

  title={Mechanisms of EF-Tu, a pioneer GTPase.},
  author={Ivo M Krab and Andrea Parmeggiani},
  journal={Progress in nucleic acid research and molecular biology},
This review considers several aspects of the function of EF-Tu, a protein that has greatly contributed to the advancement of our knowledge of both protein biosynthesis and GTP-binding proteins in general. A number of topics are described with emphasis on the function-structure relationships, in particular of EF-Tu's domains, the nucleotide-binding site, and the magnesium-binding network. Aspects related to the interaction with macromolecular ligands and antibiotics and to folding and GTPase… CONTINUE READING