Mechanisms of Doxorubicin Toxicity in Pancreatic β-Cells.

Abstract

Exposure to chemotherapeutic agents has been linked to an increased risk of type 2 diabetes (T2D), a disease characterized by both the peripheral insulin resistance and impaired glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. Using the rat β-cell line INS-1 832/13 and isolated mouse pancreatic islets, we investigated the effect of the… (More)
DOI: 10.1093/toxsci/kfw096

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