Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy

@article{Singh2008MechanismsOD,
  title={Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy},
  author={Dhruv K. Singh and P H Winocour and Ken Farrington},
  journal={Nature Clinical Practice Nephrology},
  year={2008},
  volume={4},
  pages={216-226}
}
Diabetic nephropathy is traditionally considered to be a primarily glomerular disease, although this contention has recently been challenged. Early tubular injury has been reported in patients with diabetes mellitus whose glomerular function is intact. Chronic hypoxia of the tubulointerstitium has been recognized as a mechanism of progression that is common to many renal diseases. The hypoxic milieu in early-stage diabetic nephropathy is aggravated by manifestations of chronic hyperglycemia… CONTINUE READING