Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus

@article{Cook2006MechanismsOD,
  title={Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus},
  author={H Terence Cook and Marina Botto},
  journal={Nature Clinical Practice Rheumatology},
  year={2006},
  volume={2},
  pages={330-337}
}
Complement activation is common in patients with systemic lupus erythematosus (SLE), resulting in hypocomplementemia and deposition of complement at sites of tissue damage. The availability of mice with specific deficiencies of components of the complement system has provided new insights into the mechanisms by which complement might be involved in autoimmunity and tissue injury in SLE. In humans, deficiencies of early components of the classical complement pathway are strongly associated with… CONTINUE READING

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