Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence

@article{Aigner2007MechanismsOD,
  title={Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence},
  author={Thomas Aigner and Stefan S{\"o}der and Pia Margarethe Gebhard and A Mcalinden and Jennifer Haag},
  journal={Nature Clinical Practice Rheumatology},
  year={2007},
  volume={3},
  pages={391-399}
}
The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are mainly responsible for the anabolic–catabolic balance required for matrix maintenance and tissue function. In addition to the severe changes in the extracellular matrix, the cells also display abnormalities during osteoarthritic cartilage degeneration, such as inappropriate activation of anabolic and… CONTINUE READING
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