Mechanisms of Disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8

@article{Friesema2006MechanismsOD,
  title={Mechanisms of Disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8},
  author={Edith C. H. Friesema and Jurgen Jansen and Heike Heuer and Marija Trajkovic and Karl -Heinz Bauer and Theo J. Visser},
  journal={Nature Clinical Practice Endocrinology &Metabolism},
  year={2006},
  volume={2},
  pages={512-523}
}
The actions and the metabolism of thyroid hormone are intracellular events that require the transport of iodothyronines across the plasma membrane. It is increasingly clear that this process does not occur by simple diffusion, but is facilitated by transport proteins. Only recently have iodothyronine transporters been identified at the molecular level, of which organic anion transporting polypeptide 1C1 and monocarboxylate transporter 8 (MCT8) deserve special mention, because of their high… CONTINUE READING

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