Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

@article{Sartor2006MechanismsOD,
  title={Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis},
  author={R. Balfour Sartor},
  journal={Nature Clinical Practice Gastroenterology \&Hepatology},
  year={2006},
  volume={3},
  pages={390-407}
}
  • R. Sartor
  • Published 1 July 2006
  • Medicine
  • Nature Clinical Practice Gastroenterology &Hepatology
Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain uncertain, results from research in animal models, human genetics, basic science and clinical trials have provided important new insights into the pathogenesis of chronic, immune-mediated, intestinal inflammation. These studies indicate that Crohn's disease and ulcerative colitis are heterogeneous diseases characterized by… 
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