Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides

@article{Kallenberg2006MechanismsOD,
  title={Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides},
  author={Cees G. M. Kallenberg and Peter Heeringa and Coen A. Stegeman},
  journal={Nature Clinical Practice Rheumatology},
  year={2006},
  volume={2},
  pages={661-670}
}
The presence of antibodies against neutrophil cytoplasmic constituents (antineutrophil cytoplasmic autoantibodies) is a characteristic of pauci immune vasculitides. [...] Key ResultsThese neutrophils can be stimulated by ANCA, without priming. In vivo, transfer of splenocytes from myeloperoxidase-deficient mice immunized with mouse myeloperoxidase into wild-type mice resulted in pauci-immune systemic vasculitis. A similar experiment in PR3-deficient mice did not cause significant vasculitic lesions. Together… Expand Abstract

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