Mechanisms of Disease: cancer stem cells—targeting the evil twin

  title={Mechanisms of Disease: cancer stem cells—targeting the evil twin},
  author={Andreas Trumpp and Otmar Dieter Wiestler},
  journal={Nature Clinical Practice Oncology},
Classical antineoplastic treatments such as chemotherapy or radiation can efficiently eradicate the majority of proliferating and genetically unstable malignant cells within neoplastic lesions. There is increasing evidence, however, that these regimens frequently fail to eliminate a minor subpopulation of resistant tumor cells that have distinct features of somatic stem cells. These serve as a reservoir for disease recurrence, and are the origin of metastatic growth. These so-called cancer stem… CONTINUE READING


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