Mechanisms of Disease: astrocytes in neurodegenerative disease

  title={Mechanisms of Disease: astrocytes in neurodegenerative disease},
  author={N. Maragakis and J. Rothstein},
  journal={Nature Clinical Practice Neurology},
  • N. Maragakis, J. Rothstein
  • Published 2006
  • Medicine
  • Nature Clinical Practice Neurology
  • The term neurodegenerative disease refers to the principal pathology associated with disorders such as amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease and Parkinson's disease, and it is presumed that neurodegeneration results in the clinical findings seen in patients with these diseases. Decades of pathological and physiological studies have focused on neuronal abnormalities in these disorders, but it is becoming increasingly evident that astrocytes are also important… CONTINUE READING
    710 Citations
    Reactive Astrocytes as Drug Target in Alzheimer's Disease
    • 26
    • PDF
    Targeting Glial Cells to Elucidate the Pathogenesis of Huntington’s Disease
    • 45
    Inflammation in Parkinson's disease.
    • 68
    Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease.
    • 231
    • Highly Influenced
    • PDF
    Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
    • 78
    • PDF
    The contribution of astrocytes to Alzheimer's disease.
    • Amy M. Birch
    • Biology, Medicine
    • Biochemical Society transactions
    • 2014
    • 26
    Phenotypic heterogeneity of astrocytes in motor neuron disease
    • 10
    The multi-dimensional roles of astrocytes in ALS
    • 75


    Cellular pathology of Parkinson’s disease: astrocytes, microglia and inflammation
    • 329
    Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes
    • 91
    • PDF
    Widespread cytoskeletal pathology characterizes corticobasal degeneration.
    • 265
    Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System Degeneration
    • 136
    • PDF
    Glutamate transporters: animal models to neurologic disease
    • 337