Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure

@article{Feldman2005MechanismsOD,
  title={Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure},
  author={David S. Feldman and Cynthia A. Carnes and William T. Abraham and Michael R. Bristow},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  year={2005},
  volume={2},
  pages={475-483}
}
β-adrenergic signaling is an important regulator of myocardial function. During the progression of heart failure (HF), a reproducible series of biochemical events occurs that affects β-adrenergic receptor (β-AR) signaling and cardiac function. Furthermore, there are pathophysiologic alterations in the expression and regulation of proteins that are regulated by β-ARs during HF. Analyses of these complex signaling pathways have led to a better understanding of HF mechanisms and the use of… CONTINUE READING

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