Mechanisms of Deubiquitinase Specificity and Regulation.

  title={Mechanisms of Deubiquitinase Specificity and Regulation.},
  author={Tycho E. T. Mevissen and David Komander},
  journal={Annual review of biochemistry},
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regulates a plethora of cellular processes in distinct manners. Simple monoubiquitination events coexist with more complex forms of polyubiquitination, the latter featuring many different chain architectures. Ubiquitin can be subjected to further posttranslational modifications (e.g., phosphorylation and acetylation) and can also be part of mixed polymers with ubiquitin-like modifiers such as… 

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