Mechanisms of Decreased Susceptibility to-Defensins by Treponema denticola

  title={Mechanisms of Decreased Susceptibility to-Defensins by Treponema denticola},
  author={Catherine A Brissette and Sheila A Lukehart},
Treponema denticola, a periodontal pathogen, is relatively resistant to human beta-defensins, which are small cationic antimicrobial peptides produced by a number of cells, including the gingival epithelium. Using two independent methods, we previously demonstrated that T. denticola proteases are not responsible for decreased vulnerability to defensins. In this study, we confirmed that the major outer membrane protease, dentilisin, is not responsible for T. denticola insensitivity to defensins… CONTINUE READING


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