Mechanisms of DNA double strand break repair and chromosome aberration formation.

  title={Mechanisms of DNA double strand break repair and chromosome aberration formation.},
  author={George Iliakis and Hong-Wei Wang and Ange Ronel Perrault and Wermer B{\"o}cker and B. Rosidi and Frank Windhofer and Wei-zhong Wu and Jianping Guan and Georgia I. Terzoudi and Gabriel E. Pantelias},
  journal={Cytogenetic and genome research},
  volume={104 1-4},
It is widely accepted that unrepaired or misrepaired DNA double strand breaks (DSBs) lead to the formation of chromosome aberrations. DSBs induced in the DNA of higher eukaryotes by endogenous processes or exogenous agents can in principle be repaired either by non-homologous endjoining (NHEJ), or homology directed repair (HDR). The basis on which the selection of the DSB repair pathway is made remains unknown but may depend on the inducing agent, or process. Evaluation of the relative… CONTINUE READING
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